Approximate Information and Accelerating for High-throughput Heterogeneous Data Analysis with Linear Mixed Models

Linear mixed models are frequently used for analysing heterogeneous data in a 1 broad range of applications. The restricted maximum likelihood method is often preferred to 2 estimate co-variance parameters in such models due to its unbiased estimation of the underlying 3 variance parameters. The restricted log-likelihood function involves log determinants of a 4 complicated co-variance matrix. An efficient statistical estimate of the underlying model parameters 5 and quantifying the accuracy of the estimation requires the first derivatives and the second 6 derivatives of the restricted log-likelihood function, i.e., the observed information. Standard 7 approaches to compute the observed information and its expectation, the Fisher information, is 8 computationally prohibitive for linear mixed models with thousands random and fixed effects. 9 Customized algorithms are of highly demand to keep mixed models analysis scalable for increasing 10 high-throughput heterogeneous data sets. In this paper, we explore how to leverage an averaged 11 information splitting technique and dedicate matrix transform to significantly reduce computations 12 and to accelerate computing. Together with a fill-in reducing multi-frontal sparse direct solver, the 13 averaged information splitting approach improves the performance of the computation process. 14